Strain

Lacticaseibacillus rhamnosus GG

Strain: ATCC 53103

One of the most extensively studied probiotic strains worldwide.

Also known as: Lactobacillus rhamnosus GG ATCC 53103, Lactobacillus rhamnosus GG, L. rhamnosus GG, ATCC 53103, LGG
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Scientific overview

Lactobacillus rhamnosus GG (LGG), also classified as Lacticaseibacillus rhamnosus GG, is a probiotic bacterial strain originally isolated from the human intestinal microbiota. It is identified by the strain designation ATCC 53103.

Taxonomy

Rank
Strain
Scientific name
Lacticaseibacillus rhamnosus GG

Biological mechanisms

Research has investigated several biological characteristics of LGG, including survival through gastrointestinal conditions, adhesion properties, interaction with intestinal epithelial cells, and communication with host immune pathways.

Research

LGG has been studied extensively in human and laboratory research, particularly in areas related to gastrointestinal health, microbiome interactions, diarrhea-associated conditions, and immune responses. The number of publications reflects research activity rather than a direct measure of clinical effectiveness.

496 linked publications
0 randomized trials
262 high-evidence publications

Areas studied

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Safety

LGG is one of the best-characterized probiotic strains in scientific literature. Safety and effectiveness can depend on the population studied, dosage, formulation, and specific health context.

Selected scientific publications

Selected publications from the research database connected to this microorganism.

Systematic review and meta-analysis on probiotics as treatment for food allergies among pediatric patients: A 2024 update.

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2025 · Meta-analysis

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The effects of GG supplementation on gastrointestinal and respiratory outcomes: a systematic review and meta-analysis of randomized controlled trials.

Food & function · 2025 · Meta-analysis

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A systematic review of the beneficial effects of prebiotics, probiotics, and synbiotics on ADHD.

Neuropsychopharmacology reports · 2024 · Systematic Review

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Lactobacillus rhamnosus GG as a probiotic for preterm infants: a strain specific systematic review and meta-analysis.

European journal of clinical nutrition · 2024 · Meta-analysis

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Probiotics for management of functional abdominal pain disorders in children.

The Cochrane database of systematic reviews · 2023 · Meta-analysis

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Trimethylamine N-oxide reduction is related to probiotic strain specificity: A systematic review.

Nutrition research (New York, N.Y.) · 2022 · Systematic Review

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