Several probiotic strains and multispecies formulations have been studied for anxiety, with evidence suggesting potential benefits, though strain-specific effects and study limitations exist.
Multiple high-quality systematic reviews and meta-analyses indicate that probiotics may improve anxiety symptoms, though results vary by strain, population, and study design. Lactobacillus rhamnosus HN001 showed significant reductions in postpartum anxiety symptoms. Multispecies probiotic supplements demonstrated improvements in anxiety and mood in healthy older adults and working adults. Psychobiotic formulations improved anxiety in surgical oncology patients. Some studies report mixed or low-certainty evidence, and many do not specify strains. Animal studies suggest potential mechanisms involving serotonergic and GABAergic systems for specific strains (P72 and P77), but human evidence is limited. Overall, probiotics appear promising as adjunctive interventions for anxiety, but further large, strain-specific RCTs with long-term follow-up are needed.
Evidence is high quality and strain-specific; studied in pregnant/postpartum women.
Specific strains not detailed; described as psychobiotics producing neuroactive substances.
Strain details often not specified; effects may vary by population and intervention duration.
Evidence is preclinical and low certainty; human effects unknown.
Probiotics were generally well tolerated with no significant increase in adverse events reported across studies. However, safety data are limited for some strains and populations, and long-term safety requires further study.
Many studies do not specify probiotic strains, limiting strain-specific conclusions. High heterogeneity exists in study populations, probiotic formulations, dosages, and durations. Some evidence is from animal models or low-certainty studies. More large-scale, high-quality RCTs with long-term follow-up are needed to confirm efficacy and optimal strains for anxiety.
These products contain microorganisms identified in the research analysis above.
Lacticaseibacillus rhamnosus HN001
Strain code: HN001
CFU: 50 Billion CFU
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