Probiotics show potential benefits for certain skin conditions like acne and psoriasis, but evidence is mixed and strain-specific effects are important. Lactobacillus strains have some evidence for acne and eczema, though benefits for eczema are limited. Probiotics may improve psoriasis outcomes when combined with other treatments.
What the research shows
High-quality randomized controlled trials and meta-analyses indicate that probiotics can enhance acne treatment outcomes when combined with antibiotics, particularly for lesions on the forehead, chin, and nose (PMID 39410868). Topical Lactobacillus paracasei lotion is effective and safe for mild to moderate acne, comparable to benzoyl peroxide with fewer side effects (PMID 35384257). However, a meta-analysis found no significant benefit of Lactobacillus-based probiotics alone in reducing acne lesion counts compared to placebo or benzoyl peroxide (PMID 41853869). For psoriasis, systematic reviews and meta-analyses suggest probiotic supplementation may reduce disease severity and improve quality of life, though evidence is moderate to high and often combined with prebiotics or other treatments (PMIDs 40107339, 37446403, 38551321, 38850443). For eczema, a high-quality meta-analysis found that Lactobacillus probiotics probably make little or no difference in patient-rated symptoms or quality of life, with only slight reductions in investigator-rated severity scores (PMID 30480774). Probiotics appear safe with minimal adverse effects reported across studies. Limitations include heterogeneity in probiotic strains, doses, study designs, and small sample sizes in some trials. More research is needed to clarify strain-specific effects and optimal treatment protocols.
Best studied probiotic strains
Lactobacillus paracasei MSMC 39-1
Topical application; demonstrated anti-inflammatory effects and inhibition of C. acnes in vitro.
Lactobacillus species (general)
Evidence mixed; benefits may depend on combination with antibiotics and specific strains.
Who may benefit
Safety
Probiotics were generally safe with no significant adverse effects reported in the studies reviewed. Some gastrointestinal symptoms were noted in eczema trials but were not significantly increased compared to controls. Topical probiotic lotion had fewer side effects than benzoyl peroxide.
Limitations
Studies vary in probiotic strains, doses, and treatment durations. Some trials had small sample sizes or non-randomized designs. Acne studies showed heterogeneity and some conflicting results, especially regarding Lactobacillus probiotics alone. Psoriasis studies often combined probiotics with prebiotics or other therapies, complicating attribution of effects. More standardized, large-scale RCTs are needed to confirm strain-specific benefits and optimal protocols.
PubMed sources
| Study | Type | Year | PMID |
|---|---|---|---|
| Evaluating the Effectiveness of Probiotic Supplementation in Combination With Doxycycline for the Treatment of Moderate Acne: A Randomized Double-Blind Controlled Clinical Trial. Journal of cosmetic dermatology |
Randomized Controlled Trial | 2025 | 39410868 |
| Alterations of gut microbiota for the onset and treatment of psoriasis: A systematic review. European journal of pharmacology |
Systematic Review | 2025 | 40107339 |
| Transforming Psoriasis Care: Probiotics and Prebiotics as Novel Therapeutic Approaches. International journal of molecular sciences |
Clinical Trial | 2023 | 37446403 |
| Evidence-based dietary recommendations for patients with psoriasis: A systematic review. Clinical nutrition (Edinburgh, Scotland) |
Systematic Review | 2025 | 39987781 |
| Probiotics for treating eczema. The Cochrane database of systematic reviews |
Meta-analysis | 2018 | 30480774 |
| Efficacy of probiotic-derived lotion from Lactobacillus paracasei MSMC 39-1 in mild to moderate acne vulgaris, randomized controlled trial. Journal of cosmetic dermatology |
Randomized Controlled Trial | 2022 | 35384257 |
| Efficacy of probiotic supplementation in the treatment of psoriasis-A systematic review and meta-analysis. Journal of cosmetic dermatology |
Meta-analysis | 2024 | 38551321 |
| Modulation of the skin and gut microbiome by psoriasis treatment: a comprehensive systematic review. Archives of dermatological research |
Systematic Review | 2024 | 38850443 |
| Does Probiotic Consumption Enhance Wound Healing? A Systematic Review. Nutrients |
Systematic Review | 2021 | 35010987 |
| Lactobacillus-Based Microbiome Therapy for Acne Vulgaris: A GRADE Systematic Review and Meta-Analysis of Randomized Controlled Trials. Journal of cosmetic dermatology |
Meta-analysis | 2026 | 41853869 |